The IPA Enlightenment Masterclass Series

Shedding Light on Nanoparticle Science

March 12, 2021 (9am US ET, 2pm GMT, 3pm CET)

Registration Link

Join the IPA for the first program of the Enlightenment Masterclass Series - Shedding Light on Nanoparticle Science.

Register for the congress here. Registration is free.

Chairs: Pilar Acedo, University College London, UK and Anne-Laure Bulin, University Grenoble Alpes INSERM, France

List of Speakers

Title: Control of Resistant Pneumonia using extracorporeal illumination 

Presenter: Vanderlei S. Bagnato 

Affiliation: IFSC-University of São Paulo - Brazil

Abstract: We are producing a  photosensitizer by creating a nanoemulsion composed of  ICG and glyceryl trioctanoate (commonly used in medications and personal care products).  This is  administered  directly to the lungs via nebulization to a well-established murine model of Sudden Acute Respiratory Syndrome. We have demonstrated many aspects of this type of treatment where illumination is done extracorporeal. In this presentation we present the results of the experiments using small animal models as well as the experiments with pigs. The whole process seems very promising for the control of resistant pneumonia.

Title: Raman Nanotheranostics - how can inelastic scattering add value?

Presenter: Nicholas Stone

Affiliation: Professor of Biomedical Imaging and Biosensing - University of Exeter - UK & Honorary Consultant Clinical Scientist - Royal Devon and Exeter NHS Foundation Trust

Abstract: Raman Nanotheranostics (RaNT) combines the molecular specificity and signal multiplexing capability of Raman spectroscopy, with surface enhanced Raman spectroscopy and nanoplasmonics. This enables the identification of specific functionalised nanoparticles at depths of many cm in tissues as well as localised targeted heating and providing a direct measure of the local environment of the particle, such as temperature and pH, thus enabling a tailored feedback on the treatment in real-time.

Title: Photodynamic liposomes for chemophototherapy 

Presenter: Jonathan Lovell

Affiliation: Department of Biomedical Engineering, State University of New York at Buffalo - USA

Abstract: We have developed liposomes that are doped with a small amount of a photosensitizing lipid; porphyrin-phospholipid (PoP). Long-circulating doxorubicin (Dox) in porphyrin–phospholipid (PoP) liposomes (LC-Dox-PoP) is similar to the FDA-approved liposomal doxorubicin form of Doxil, but incorporates a phospholipid-like photosensitizer (2 mole %) in the bilayer of Dox-loaded stealth liposomes. A liposomal irinotecan formulation has been made in a similar manner based on the FDA-approved liposomal Onivyde. Drugs loaded in PoP liposomes, as well as the PoP itself are stable and exhibit long circulation times in blood. However, red laser irradiation rapidly releases the entrapped drug from the carrier. When mouse or rat tumors are treated with these chemophototherapy agents, a single treatment is frequently sufficient to ablate established tumors at a relatively low chemotherapy dose of drug. Pharmacokinetic analysis shows that a major mechanism for the efficacy pertains to enhanced drug delivery following permeabilization of tumor blood vessels damaged by PDT. We will
discuss our experience and outlook for this approach to chemophotherapy as a strong ablation modality with systemic drug delivery.